P0300 on a 2022 Honda Pilot

Random or Multiple Cylinder Misfire

P0300 on a 2022 Honda Pilot indicates random or multiple cylinder misfire. Stop driving and diagnose it before continuing — it can signal an unsafe condition. The most common cause is worn or fouled spark plugs (all cylinders due for replacement) (typically $60–$350). Confirm the root cause before replacing parts.

Severity: high Do not drive Mid-size SUV 2020-2024 Honda Pilot

Reviewed by MECH AI Editorial · Last verified

What does P0300 mean on a 2022 Honda Pilot?

P0300 is set when the engine control module's misfire monitor detects that combustion is failing in more than one cylinder, or that misfires are occurring randomly across cylinders rather than being isolated to a single one. The misfire monitor works by measuring tiny variations in crankshaft rotational speed — a missed combustion event causes the crankshaft to decelerate by a detectable amount. When the ECM cannot attribute the event to a single cylinder, it sets P0300.

This guide covers P0300 across the 2020-2024 Honda Pilot generation — the symptoms, causes, and diagnostic steps below apply to every model year from 2020 through 2024.

Is it safe to drive a 2022 Honda Pilot with P0300?

No. P0300 is a high-severity code on the 2022 Honda Pilot — avoid driving until it is diagnosed and repaired, as it can indicate an unsafe condition or risk further damage.

What are the symptoms of P0300 on a 2022 Honda Pilot?

What causes P0300 on a 2022 Honda Pilot?

Cause Likelihood Estimated repair (USD)
Worn or fouled spark plugs (all cylinders due for replacement) Especially common past 80,000 miles on platinum or iridium plugs. Most common $60–$350
Failing ignition coils — coil-on-plug systems Most common $80–$600
Vacuum leak causing lean misfire across all cylinders Common $80–$500
Low fuel pressure (weak pump, clogged filter) Common $80–$900
Clogged or leaking fuel injectors Occasional $150–$1,500
Carbon-fouled intake valves (direct-injection engines) Occasional $400–$900
Low engine compression (worn rings, burnt valve, head gasket) Rare $1,500–$5,000
Failed crankshaft or camshaft position sensor causing timing issues Rare $150–$550

How to diagnose this on a 2022 Honda Pilot

  1. Pull every code, including pending and freeze-frame data

    Read all stored, pending, and permanent codes. Note which cylinder(s) show misfire counts in mode 6 or the manufacturer-specific misfire PID. Freeze-frame data tells you the engine load, RPM, and temperature when the misfire occurred — critical for narrowing down the cause.

    Tools: Scan tool with mode 6 / misfire counters

  2. Swap ignition coils between cylinders

    On a coil-on-plug system, move the coil from a suspect cylinder to a known-good cylinder. Clear codes, drive, and re-read. If the misfire follows the coil, the coil is bad. If it stays in the same cylinder, the coil is not the cause.

    Tools: Socket set, Torque wrench (for plug torque on reassembly)

  3. Inspect spark plugs visually

    Remove all spark plugs. Compare their appearance. A black, sooty plug indicates a rich condition for that cylinder. A wet, fuel-smelling plug means no spark or no compression on that cylinder. White or blistered ceramic indicates an overly lean condition. Replace the full set if any are out of spec or past service interval.

    Tools: Spark plug socket, Extension and ratchet, Anti-seize and torque wrench

  4. Test fuel pressure under load

    Connect a fuel pressure gauge and observe pressure at idle, snap-throttle, and steady cruise. A weak pump may hold pressure at idle but drop under load — the time pattern matters as much as the absolute reading.

    Tools: Fuel pressure gauge

  5. Perform a cylinder compression or relative-compression test

    If misfires persist after ignition and fuel system work, perform a compression test on each cylinder, or use a scan tool's relative compression function. Cylinders more than 15 % below the rest indicate a mechanical problem (rings, valves, or head gasket).

    Tools: Compression tester, Scan tool with relative compression

NHTSA complaints & recalls for the 2022 Honda Pilot

Owner-reported safety complaints and official recalls filed with the U.S. National Highway Traffic Safety Administration for the 2022 Honda Pilot. Use these to gauge how common a problem is on your specific vehicle before you start chasing Honda Pilot diagnostics.

121 owner complaints
5 involved a crash
3 reported injuries
  • ENGINE 21
  • POWER TRAIN 12
  • FORWARD COLLISION AVOIDANCE 33
  • UNKNOWN OR OTHER 27
  • ELECTRICAL SYSTEM 26

4 active recalls

  • BACK OVER PREVENTION:DISPLAY FUNCTION Jun 2023

    Honda (American Honda Motor Co.) is recalling certain 2018-2023 Odyssey, 2019-2022 Pilot, and 2019-2023 Passport vehicles. Due to a faulty Media Oriented Systems Transport (MOST) communication coaxial cable connector, the rearview camera image may not appear on the display. As…

    NHTSA campaign 23V431000
  • SERVICE BRAKES, HYDRAULIC:FOUNDATION COMPONENTS:MASTER CYLINDER Jun 2023

    Honda (American Honda Motor Co.) is recalling certain 2020-2021 Civic, 2020-2023 Ridgeline, 2021-2023 Passport, 2021-2022 Pilot, and 2020 Acura MDX vehicles. The tie rod fastener that connects the brake booster and the brake master cylinder may have been improperly assembled dur…

    NHTSA campaign 23V458000
  • AIR BAGS:SENSOR:OCCUPANT CLASSIFICATION:FRONT PASSENGER Feb 2024

    Honda (American Honda Motor Co.) is recalling certain 2020-2022 Pilot, Accord, Civic sedan, HR-V, Odyssey, 2020 Civic coupe, Fit, 2021-2022 Civic hatchback, 2021 Civic Type R, Insight, 2020-2021 CR-V, CR-V Hybrid, Passport, Ridgeline, Accord Hybrid, 2020 Acura MDX, 2022 Acura MDX…

    NHTSA campaign 24V064000
  • AIR BAGS:SENSOR:OCCUPANT CLASSIFICATION:FRONT PASSENGER May 2026

    Honda (American Honda Motor Co.) is recalling certain 2018-2021, 2023 Acura TLX, 2019-2024 RDX, 2017-2020, 2022-2026 MDX, 2017-2021, 2023, 2025 Honda Ridgeline, 2017-2022 Pilot, 2019-2021 Passport, 2018-2026 Odyssey, 2019-2022 Insight, 2019-2021 HR-V, 2018-2020 Fit, 2020-2022 CR-…

    NHTSA campaign 26V332000

How do I fix P0300 on a 2022 Honda Pilot?

About the 2020-2024 Honda Pilot

The 2020-2024 Honda Pilot was commonly sold with the following powertrains: 3.5L V6. Common trims include LX, EX, EX-L, Touring, Elite, TrailSport.

Is it safe to drive with a P0300?

If the Check Engine Light is flashing, no — pull over and tow the vehicle. A flashing light means raw fuel is reaching the catalytic converter, where it will combust and destroy the substrate within minutes. Replacement catalysts are $600–$2,400. Driving home is not worth that risk.

If the light is steady, the misfire is intermittent or minor. The vehicle can usually be driven short distances to a repair shop, but every mile adds risk of catalyst damage.

Why P0300 with no cylinder-specific code is harder to diagnose

P0301 through P0308 narrow the problem to a single cylinder. P0300 alone means the misfire is jumping cylinders or affecting all of them — which points to a systemic cause: ignition system, fuel system, vacuum, or mechanical. Always start with mode 6 misfire counts to see if any cylinder is statistically worse, even if no per-cylinder code has matured yet.

When to suspect compression vs. ignition vs. fuel

Symptom patternLikely root cause
Cold start misfire that clears warmCarbon-fouled valves or worn plugs
Misfire only under loadWeak ignition coils or low fuel pressure
Misfire only at idleVacuum leak or dirty injectors
Misfire on the same cylinder despite coil/plug swapCompression problem (valve or rings)
Random multi-cylinder misfire after fuel-upBad fuel

Related diagnostic codes