P0300 on a 2022 GMC Sierra 1500
Random or Multiple Cylinder Misfire
P0300 on a 2022 GMC Sierra 1500 indicates random or multiple cylinder misfire. Stop driving and diagnose it before continuing — it can signal an unsafe condition. The most common cause is worn or fouled spark plugs (all cylinders due for replacement) (typically $60–$350). Confirm the root cause before replacing parts.
What does P0300 mean on a 2022 GMC Sierra 1500?
P0300 is set when the engine control module's misfire monitor detects that combustion is failing in more than one cylinder, or that misfires are occurring randomly across cylinders rather than being isolated to a single one. The misfire monitor works by measuring tiny variations in crankshaft rotational speed — a missed combustion event causes the crankshaft to decelerate by a detectable amount. When the ECM cannot attribute the event to a single cylinder, it sets P0300.
This guide covers P0300 across the 2020-2024 GMC Sierra 1500 generation — the symptoms, causes, and diagnostic steps below apply to every model year from 2020 through 2024.
Is it safe to drive a 2022 GMC Sierra 1500 with P0300?
No. P0300 is a high-severity code on the 2022 GMC Sierra 1500 — avoid driving until it is diagnosed and repaired, as it can indicate an unsafe condition or risk further damage.
What are the symptoms of P0300 on a 2022 GMC Sierra 1500?
- Check Engine Light flashing (severe misfire) or steady (minor misfire)
- Rough idle and noticeable engine shake at a stop
- Hesitation or stumble under load
- Loss of power, especially at higher RPM or on hills
- Reduced fuel economy
- Smell of raw fuel from the exhaust
- Possible catalytic converter damage with prolonged operation
What causes P0300 on a 2022 GMC Sierra 1500?
| Cause | Likelihood | Estimated repair (USD) |
|---|---|---|
| Worn or fouled spark plugs (all cylinders due for replacement) Especially common past 80,000 miles on platinum or iridium plugs. | Most common | $60–$350 |
| Failing ignition coils — coil-on-plug systems | Most common | $80–$600 |
| Vacuum leak causing lean misfire across all cylinders | Common | $80–$500 |
| Low fuel pressure (weak pump, clogged filter) | Common | $80–$900 |
| Clogged or leaking fuel injectors | Occasional | $150–$1,500 |
| Carbon-fouled intake valves (direct-injection engines) | Occasional | $400–$900 |
| Low engine compression (worn rings, burnt valve, head gasket) | Rare | $1,500–$5,000 |
| Failed crankshaft or camshaft position sensor causing timing issues | Rare | $150–$550 |
How to diagnose this on a 2022 GMC Sierra 1500
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Pull every code, including pending and freeze-frame data
Read all stored, pending, and permanent codes. Note which cylinder(s) show misfire counts in mode 6 or the manufacturer-specific misfire PID. Freeze-frame data tells you the engine load, RPM, and temperature when the misfire occurred — critical for narrowing down the cause.
Tools: Scan tool with mode 6 / misfire counters
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Swap ignition coils between cylinders
On a coil-on-plug system, move the coil from a suspect cylinder to a known-good cylinder. Clear codes, drive, and re-read. If the misfire follows the coil, the coil is bad. If it stays in the same cylinder, the coil is not the cause.
Tools: Socket set, Torque wrench (for plug torque on reassembly)
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Inspect spark plugs visually
Remove all spark plugs. Compare their appearance. A black, sooty plug indicates a rich condition for that cylinder. A wet, fuel-smelling plug means no spark or no compression on that cylinder. White or blistered ceramic indicates an overly lean condition. Replace the full set if any are out of spec or past service interval.
Tools: Spark plug socket, Extension and ratchet, Anti-seize and torque wrench
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Test fuel pressure under load
Connect a fuel pressure gauge and observe pressure at idle, snap-throttle, and steady cruise. A weak pump may hold pressure at idle but drop under load — the time pattern matters as much as the absolute reading.
Tools: Fuel pressure gauge
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Perform a cylinder compression or relative-compression test
If misfires persist after ignition and fuel system work, perform a compression test on each cylinder, or use a scan tool's relative compression function. Cylinders more than 15 % below the rest indicate a mechanical problem (rings, valves, or head gasket).
Tools: Compression tester, Scan tool with relative compression
NHTSA complaints & recalls for the 2022 GMC Sierra 1500
Owner-reported safety complaints and official recalls filed with the U.S. National Highway Traffic Safety Administration for the 2022 GMC Sierra 1500. Use these to gauge how common a problem is on your specific vehicle before you start chasing GMC Sierra 1500 diagnostics.
- ENGINE 207
- POWER TRAIN 92
- STRUCTURE 90
- ELECTRICAL SYSTEM 75
- UNKNOWN OR OTHER 70
6 active recalls
- EXTERIOR LIGHTING:BRAKE LIGHTS Jun 2022
General Motors (GM) has decided that certain 2022 model year Chevrolet Silverado, and GMC Sierra vehicles equipped with an accessory sport bar. The accessory sport bar contains a high-mounted brake light that may not function. In addition, it may block the vehicle's existing hi…
NHTSA campaign 22V463000 - EXTERIOR LIGHTING:LIGHTING CONTROL MODULE:SOFTWARE Dec 2022
General Motors, LLC (GM) is recalling certain 2020-2023 Cadillac CT4 and CT5; 2021-2023 Buick Envision; and 2022-2023 Cadillac Escalade and Escalade ESV, Chevrolet Silverado 1500, Suburban, Tahoe, GMC Sierra 1500, Yukon, and Yukon XL vehicles. The daytime running lights (DRLs) m…
NHTSA campaign 22V903000 - POWER TRAIN:AUTOMATIC TRANSMISSION:CONTROL MODULE:SOFTWARE Oct 2024
General Motors, LLC (GM) is recalling certain 2020-2022 Chevrolet Silverado 1500, 2500, 3500, GMC Sierra 1500, 2500, 3500, 2021 Cadillac Escalade, Escalade ESV, Chevrolet Tahoe, Suburban, GMC Yukon, and Yukon XL vehicles equipped with diesel engines. The transmission control val…
NHTSA campaign 24V797000 - STRUCTURE:BODY:BUMPERS:ACTIVE SHUTTERS/GRILL Feb 2025
General Motors, LLC (GM) is recalling certain 2022 GMC Sierra 1500 vehicles equipped with chrome front grille deflectors. The attachments that hold the front grille deflectors in place may fracture, resulting in grille detachment.…
NHTSA campaign 25V060000
How do I fix P0300 on a 2022 GMC Sierra 1500?
- Replace all spark plugs as a set with the OEM-specified part
- Replace failed ignition coil(s)
- Repair any vacuum leaks found by smoke test
- Replace fuel pump, fuel filter, or pressure regulator
- Walnut-blast intake valves (carbon buildup, direct-injection engines)
- Replace failed crankshaft or camshaft sensor
About the 2020-2024 GMC Sierra 1500
The 2020-2024 GMC Sierra 1500 was commonly sold with the following powertrains: 5.3L V8, 6.2L V8, 2.7L Turbo I4, 3.0L Duramax I6 Diesel. Common trims include Pro, SLE, Elevation, SLT, AT4, Denali.
Is it safe to drive with a P0300?
If the Check Engine Light is flashing, no — pull over and tow the vehicle. A flashing light means raw fuel is reaching the catalytic converter, where it will combust and destroy the substrate within minutes. Replacement catalysts are $600–$2,400. Driving home is not worth that risk.
If the light is steady, the misfire is intermittent or minor. The vehicle can usually be driven short distances to a repair shop, but every mile adds risk of catalyst damage.
Why P0300 with no cylinder-specific code is harder to diagnose
P0301 through P0308 narrow the problem to a single cylinder. P0300 alone means the misfire is jumping cylinders or affecting all of them — which points to a systemic cause: ignition system, fuel system, vacuum, or mechanical. Always start with mode 6 misfire counts to see if any cylinder is statistically worse, even if no per-cylinder code has matured yet.
When to suspect compression vs. ignition vs. fuel
| Symptom pattern | Likely root cause |
|---|---|
| Cold start misfire that clears warm | Carbon-fouled valves or worn plugs |
| Misfire only under load | Weak ignition coils or low fuel pressure |
| Misfire only at idle | Vacuum leak or dirty injectors |
| Misfire on the same cylinder despite coil/plug swap | Compression problem (valve or rings) |
| Random multi-cylinder misfire after fuel-up | Bad fuel |